Turns out those psychedelic drugs might be good in the fight against depression.
A review, published August 18 in Nature Reviews Neuroscience, of research on this grouping of drugs generally—ranging from dissociative anesthetics such as ketamine to naturally occurring hallucinogenic compounds such as the psilocybin in majik mushrooms— shows their efficacy at treating obsessive-compulsive disorders and addiction as well as depression and anxiety, among other disorders. (Scientific American is part of the Nature Publishing Group.)
In fact, ketamine has shown promise at reducing the risk of suicide and is currently being tested in humans for effectiveness in treating bipolar disorder and addiction. Psilocybin can decrease obsessive-compulsive behaviors, or even eliminate them entirely, for as long as a full day after treatment and is being tested to reduce anxiety and depression in terminal cancer patients. Even LSD—lysergic acid diethylamide-25—can combat inflammation, among other potential therapeutic uses. "The potency is about 300 times more potent than steroidal anti-inflammatories," says pharmacologist Charles Nichols of the Louisiana State University Health Sciences Center, who is working with the drug. "My lab is currently studying the ability of it to block or prevent inflammation in models of human inflammatory disorders, and the results are very promising so far."
The August 18 review, by psychiatrist Franz Vollenweider and neuropsychologist Michael Kometer of the University Hospital of Psychiatry in Zurich, proposes that various psychedelics' interaction with the receptors for the neurotransmitter serotonin may prove key to understanding their beneficial—and mind-bending—effects. "Psychedelics activate neuronal networks and the glutamate system that are implicated in the regulation of emotion," Vollenweider says, noting that their hallucinogenic effects can be impeded by blocking specific serotonin receptors in the brain (known as 5-HT2A). Psychedelics typically boost serotonin and may also boost the release of glutamate, according to the review authors, another neurotransmitter that has been linked to short-term but long-lasting brain functions such as learning and memory. More glutamate also has an impact on synapses. "This might result in an increased number and function of spine synapses in the prefrontal cortex," Vollenweider says.
Smoking pot and eating majik mushrooms for a healthier you...
It’s like I went to sleep and woke up living in the world my friends and I would dream up in those long lofty "We're gonna change the world maaaan!!!!" conversations teenage boys (usually under the influence of marijuana and mushrooms).
All kidding aside, there has to be a reason why people have been eating psychedelics since the dawn of time.
Study after study has shown the positive effects of psychedelics (such as marijuana and majik mushrooms) that have been subject to decades of demonization and persecution.
Maybe those "mad scientists" in the 50s and 60s that came up with this shit -such as those notorious secret government LSD experiments- were right with their hypothesis that taking psychedelic "trips" expanded the mind and its capabilities.
not that I am saying to go run out to your nearest cow field and listen to some live Phish bootlegs after eating your freshly picked wears... Not at all...Just that maybe it is time for us to rethink our societal attitudes towards the respectful and responsible use of psychotropic "drugs' that occur naturally in nature and have been used by Man for millennia.